Update README.md

README.md

-# multicrispr: gRNA design
-
-[![](https://bioconductor.org/shields/build/devel/bioc/multicrispr.svg)](http://bioconductor.org/checkResults/devel/bioc-LATEST/multicrispr/)
-[![](https://bioconductor.org/shields/availability/3.12/multicrispr.svg)](https://bioconductor.org/packages/devel/bioc/html/multicrispr.html#archives) 
-[![](https://bioconductor.org/shields/years-in-bioc/multicrispr.svg)](https://bioconductor.org/packages/devel/bioc/html/multicrispr.html#since)
-[![](https://img.shields.io/badge/doi-10.26508/lsa.202000757-blue.svg)](https://doi.org/10.26508/lsa.202000757)
-
-
-### Installation
-
-    # Install multicrispr
-        remotes::install_git('https://gitlab.gwdg.de/loosolab/software/multicrispr.git', 
-        			    repos = BiocManager::repositories())
-    # Install azimuth
-        install.packages('reticulate')
-        reticulate::conda_create('azienv', c('python=2.7'))
-        reticulate::use_condaenv('azienv')
-        reticulate::py_install(c('azimuth', 'scikit-learn==0.17.1'), 'azienv', pip = TRUE)
-    # Index mm10 and hg38
-        BiocManager::install('BSgenome.Mmusculus.UCSC.mm10')
-        BiocManager::install('BSgenome.Hsapiens.UCSC.hg38')
-        index_genome(BSgenome.Mmusculus.UCSC.mm10::BSgenome.Mmusculus.UCSC.mm10)
-        index_genome(BSgenome.Hsapiens.UCSC.hg38::BSgenome.Hsapiens.UCSC.hg38)
-
-
-### Overview
-   
-![](https://gitlab.gwdg.de/loosolab/software/multicrispr/-/wikis/uploads/cdf31586bcf776a7a40acaaaf5172e10/overview.png)
-
+# multicrispr: gRNA design
+
+[![](https://bioconductor.org/shields/build/devel/bioc/multicrispr.svg)](http://bioconductor.org/checkResults/devel/bioc-LATEST/multicrispr/)
+[![](https://bioconductor.org/shields/availability/3.12/multicrispr.svg)](https://bioconductor.org/packages/devel/bioc/html/multicrispr.html#archives) 
+[![](https://bioconductor.org/shields/years-in-bioc/multicrispr.svg)](https://bioconductor.org/packages/devel/bioc/html/multicrispr.html#since)
+[![](https://img.shields.io/badge/doi-10.26508/lsa.202000757-blue.svg)](https://doi.org/10.26508/lsa.202000757)
+
+
+### Installation
+
+    # Install multicrispr
+        remotes::install_git('https://gitlab.gwdg.de/loosolab/software/multicrispr.git', 
+        			    repos = BiocManager::repositories())
+    # Install azimuth
+        install.packages('reticulate')
+        reticulate::conda_create('azienv', c('python=2.7'))
+        reticulate::use_condaenv('azienv')
+        reticulate::py_install(c('azimuth', 'scikit-learn==0.17.1', 'biopython=1.76'), 'azienv', pip = TRUE)
+    # Index mm10 and hg38
+        BiocManager::install('BSgenome.Mmusculus.UCSC.mm10')
+        BiocManager::install('BSgenome.Hsapiens.UCSC.hg38')
+        index_genome(BSgenome.Mmusculus.UCSC.mm10::BSgenome.Mmusculus.UCSC.mm10)
+        index_genome(BSgenome.Hsapiens.UCSC.hg38::BSgenome.Hsapiens.UCSC.hg38)
+
+
+### Overview
+   
+![](https://gitlab.gwdg.de/loosolab/software/multicrispr/-/wikis/uploads/cdf31586bcf776a7a40acaaaf5172e10/overview.png)
+